Reintroducing HRT: Physical Risks and Physical Benefits Potential Physical Benefits Adding oestrogen back into the body can produce several clinically recognised improvements: Improved thermoregulation Oestrogen helps the hypothalamus regulate temperature, reducing hot flushes and heat intolerance. Reduced morning nausea Stable oestrogen levels can calm the GI system and reduce hormone triggered nausea. Better fluid balance Oestrogen can counteract some progesterone related water retention by stabilising aldosterone activity. Improved sleep and energy Oestrogen supports serotonin and melatonin pathways, which can reduce fatigue and improve sleep quality. Reduced joint pain and stiffness Oestrogen has anti inflammatory effects that can reduce musculoskeletal discomfort. Improved cognitive clarity Oestrogen supports acetylcholine and blood flow in the brain, which can reduce fog and improve focus. These benefits occur be...